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Search Results for " fatty acid amide hydrolase "

53

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6043	PF-3845	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	PF3845 是一种有效的、选择性的和不可逆的脂肪酸酰胺水解酶（FAAH）抑制剂，Ki 为 230 nM。它是将 FAAH 的丝氨酸亲核试剂氨基甲酸酯化的共价抑制剂，可以减少疼痛感、炎症和焦虑或抑郁。
T7688	4-Nonylphenylboronic acid	FAAH	Metabolism; Neuroscience
	4-Nonylphenylboronic acid 是 FAAH 的抑制剂。
T2684	JNJ-1661010 JNJ1661010,Takeda-25,JNJ 1661010	FAAH	Metabolism; Neuroscience
	JNJ-1661010 (Takeda-25) 是一种有效的、选择性的、可以穿透血脑屏障的脂肪酸酰胺水解酶 (FAAH) 抑制剂，对大鼠和人 FAAH 的 IC50分别为 34 和 33 nM，可用于缓解疼痛的研究。
T9967	MAGL-IN-5	Lipid	Metabolism
	MAGL-IN-5 是一种非选择性脂肪酶抑制剂。
T28353	PDP-EA	FAAH	Metabolism; Neuroscience
	PDP-EA 是脂肪酸酰胺水解酶 (FAAH) 的激活剂，可增强 FAAH 的酰胺水解酶活性。
T8646	URB937	FAAH	Metabolism; Neuroscience
	URB937 是一种口服具有活性的、外周限制的FAAH 抑制剂，IC50=26.8 nM，可增加 anandamide 水平，但不能影响脑内 FAAH 水平 (无法透过血脑屏障)。
T3215	JNJ-42165279 JNJ42165279	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	JNJ-42165279 是一种 FAAH 抑制剂，抑制 hFAAH 和 rFAAH，IC50分别为70 ± 8 nM 和 313 ± 28 nM。它对其他酶、离子通道、转运蛋白和受体具有高度选择性。
T2338	JZL195	FAAH; Lipase; Autophagy	Autophagy; Metabolism; Neuroscience
	JZL195 是一种选择性有效的脂肪酸酰胺水解酶和单酰甘油脂肪酶双重抑制剂，IC50s 分别为 2 和 4 nM。
T8927	WWL 154 WWL-154	FAAH	Metabolism; Neuroscience
	WWL 154 是一种丝氨酸水解酶 (SH) 和脂肪酸酰胺水解酶 FAAH-4 抑制剂。
T4323	PF-04457845 PF04457845,PF 04457845	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	PF-04457845 是一种非常有效的选择性 FAAH 抑制剂，作用于 rFAAH 和 hFAAH，IC50分别为 7.4±0.62 nM 和 7.2±0.63 nM。
T3354	BIA 10-2474 BIA10-2474	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	BIA 10-2474 是一种长效可逆的脂肪酸酰胺水解酶抑制剂，与人类内源性大麻素系统相互作用，可增加中枢神经系统和外周组织，对大鼠大脑不同区域的 IC50值为50至70mg/kg。它用于治疗焦虑症、帕金森氏病和多发性硬化症、高血压或肥胖症的慢性疼痛。
T15802	LY2183240	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	LY2183240 是大麻素摄取阻滞剂。它是内源性大麻素降解酶脂肪酸酰胺水解酶的有效共价抑制剂。它抑制脂肪酸酰胺水解酶 (FAAH) 活性，IC50 为12.4 nM。它也抑制其他几种脑丝氨酸水解酶，对 MAG 脂肪酶、bh6 和 KIAA1363 的 IC50分别为 5.3、0.09 和 8.2 nM。
T1325	Carprofen 卡洛芬,Ridamyl,Imadyl,Rimadyl	FAAH; COX; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; Neuroscience
	Carprofen (Ridamyl) 是多靶点FAAH/COX 抑制剂，能够抑制 COX-2，COX-1 和 FAAH 的活性，IC50值分别为 3.9 μM，22.3 μM 和 78.6 μM。它是一种丙酸衍生物和非甾体抗炎药，具有抗炎、镇痛和解热活性。
T9374	AA38-3 1-Piperidinecarboxylic acid, 4-nitrophenyl ester	FAAH; Lipase; MAGL	Metabolism; Neuroscience
	AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) 是丝氨酸水解酶抑制剂，能够抑制三种 SHs：ABHD6，ABHD11 和 FAAH。
T11256	FAAH inhibitor 1 Benzothiazole analog 3	FAAH	Metabolism; Neuroscience
	FAAH inhibitor 1 (Benzothiazole analog 3) 是一种有效的脂肪酸酰胺水解酶抑制剂，IC50 为 18 nM。
T15268	FAAH-IN-2 O-Desmorpholinopropyl Gefitinib,4-(3-氯-4-氟苯氨基)-7-甲氧基喹唑啉-6-醇	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) 是一种脂肪酸酰胺水解酶的有效抑制剂。
T6714	URB-597 KDS-4103,FAAH Inhibitor II	Mitophagy; FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	URB-597 (FAAH Inhibitor II) 是一种可口服的选择性FAAH 抑制剂。它抑制大鼠脑膜、体外大鼠神经元和人肝微粒体中的 FAAH 活性，IC50分别为 5、0.5和 3 nM。它具有抗抑郁样作用，可研究缓解疼痛。
T28059	MK-4409 MK4409,MK 4409
	MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, is being investigated for the treatment of inflammatory and neuropathic pain.
T27405	GAT211 GAT-211,AZ-4,GAT 211,AZ 4,AZ4
	GAT211 is a CB1 positive allosteric modulator. GAT211 suppresses allodynia and produces synergistic antiallodynic effects with monoacylglycerol lipase and fatty acid amide hydrolase inhibitors in paclitaxel-treated mice.
T28076	MM-433593	FAAH	Metabolism; Neuroscience
	MM-433593 是一种选择性脂肪酸酰胺水解酶（FAAH-1）抑制剂，可用于治疗疼痛、炎症和其他疾病。
T63536	Dual FAAH/sEH-IN-1	FAAH; Epoxide Hydrolase	Metabolism; Neuroscience
	Dual FAAH/sEH-IN-1 是具有高度亲和力的sEH(可溶性环氧水解酶) (IC50: 9.6 nM) 和FAAH(脂肪酸酰胺水解酶) (IC50: 7 nM) 双重抑制剂，具有抗炎活性。
T15635	JZP-430	Lipase; MAGL	Metabolism
	JZP-430 是不可逆的、高度选择性的 α/β 水解酶结构域 6 抑制剂，能够靶向抑制人类 ABHD6 ，其 IC50=44 nM。
T68492	AM 374 HDSF,Hexadecanesulfonyl fluoride	FAAH	Metabolism; Neuroscience
	AM 374 (HDSF) 是一种脂肪酸酰胺水解酶(FAAH)抑制剂。AM 374 对氨基酶活性的抑制作用的IC50为 13 nM。AM 374 可用于神经系统疾病的研究。
T67896	CB2R/FAAH modulator-1	Cannabinoid Receptor; FAAH	GPCR/G Protein; Metabolism; Neuroscience
	CB2R/FAAH modulator-1是一种大麻素2型受体(CB2R)激动剂，同时也是脂肪酸酰胺水解酶(FAAH)抑制剂（IC50=4 μM），可减少促炎和增加抗炎细胞因子的产生，常用于炎症研究。对 CB2R 和 CB1R 的Kis 分别为14.8 nM 和241.3 nM。
T26311	URB532 URB-532,FAAH Inhibitor I,FAAH Inhibitor-I,URB 532
	URB532 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor.
T29045	UCM710
	UCM710 is a dual inhibitor of α/β hydrolase domain 6 (ABHD6) and fatty acid amide hydrolase (FAAH).
T68407	URB-694
	URB-694 is a fatty acid amide hydrolase (FAAH) inhibitor.
T12827	SA72	Others	Others
	SA72 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH).
T16847	SA 47	FAAH	Metabolism; Neuroscience
	SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.
T27681	JNJ-40355003 JNJ40355003
	JNJ-40355003, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, elevates the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey.
T11255	FAAH-IN-1	FAAH	Metabolism; Neuroscience
	FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
T40775	SSR411298 SSR411298
	SSR411298 is a reversible, orally active compound that selectively inhibits fatty acid amide hydrolase (FAAH). Its potential lies in the field of post-traumatic stress disorder (PTSD) research.
T71307	JNJ-40413269
	JNJ-40413269 is a competitive inhibitor of fatty acid amide hydrolase (FAAH), which demonstrates robust central target engagement, and shows efficacious in a rat model of neuropathic pain.
T71995	Decanoyl chloride
	Decanoyl Chloride is used in the synthesis of an effective metalloproteinase inhibitor. Also acts as a reagent in the synthesis of reversible α-ketoheterocycle inhibitors of fatty acid amide hydrolase as potnetial analgesics.
T28007	MDPD
	MDPD is an enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis. MDPD alleviates the growth inhibitory effects of NAE 12:0, in part by enhancing the enzymatic activity of Arabidopsis FAAH (AtFAAH).
T78593	JP104	FAAH	Metabolism; Neuroscience
	JP104为一种氨基甲酸芳基酯类化合物，其具有不可逆FAAH抑制作用，显示出约为8的pIC50值。
T61380	Carpro-AM1
	Carpro-AM1 is a compound that acts as a dual inhibitor of both fatty acid amide hydrolase (FAAH) and substrate-selective cyclooxygenase (COX). It exhibits potent inhibitory activity against FAAH, with an IC50 value of 94 nM [1].
T25918	Palmitoyl-L-aspartic acid L-N-Palmitoylaspartic acid
	Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid receptors or fatty acid amide hydrolas
T37217	N-Decanoyl p-Nitroaniline
	N-Decanoyl p-nitroaniline (DepNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its endogenous substrate anandamide (AEA). It also will hydrolyze fatty acid amides with fewer carbons and fewer double bonds than arachidonate. Exposure of DepNA to FAAH activity results in the release of the yellow colori...
T61198	FAAH/MAGL-IN-1
	FAAH/MAGL-IN-1, also known as compound SIH 3, is a highly effective inhibitor of FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). It exhibits IC50 values of 31 nM and 29 nM against FAAH and MAGL, respectively. This compound shows promising potential for advancing research in the field of neuropathic pain [1].
T33789	Oleoyl proline N-Oleoyl-l-proline
	Oleoyl proline is an N-acyl amine that can be detected in bovine brain extracts and D. melanogaster larvae using mass spectrometry. In a preclinical model of pain, mice lacking fatty acid amide hydrolase (FAAH KO) had decreased N-oleoyl proline levels in
T62558	FAAH-IN-5
	FAAH-IN-5 (Compound 7) 是一种相对选择性的、不可逆的脂肪酸酰胺水解酶 (FAAH) 抑制剂 (IC50: 10.5 nM)。FAAH-IN-5 具有低 PAMPA (平行人工膜渗透性试验) 透过性。
T38223	N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
	N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxisome proliferator-activated receptor α (PPARα) in a luciferase reporter assay and, in rats, it decreases food intake. It does not inhibit fatty acid amide hydrolase (FAAH).
T38143	Elaidamide
	Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A2 (PLA2).3 In vivo, elaidamide (10 mg/animal) induces physiological sleep in rats.1References1. Cravatt, B.F., Prospero-Garcia, O., Siuzdak, G., et al. Chemical characterization of a family of brain lipids that induce sleep. Science 268(5216), 1506-150...
T73302	FAAH-IN-7
	FAAH-IN-7 是一种可逆且有效的FAAH 抑制剂，IC50为 8.29 nM。FAAH-IN-7 能够抑制 1321N1星形胶质细胞氧化应激，在离体神经炎症模型中表现出显著的神经保护作用。
T78674	Isopropyl dodec-11-enylfluorophosphonate IDEFP	FAAH	Metabolism; Neuroscience
	Isopropyl dodec-11-enylfluorophosphonate (IDEFP) 为有机磷酯类化合物，能抑制中枢大麻素受体 (cannabinoid receptor) (CB1) 并具有相似的效力抑制FAAH（IC50s = 2 nM）。
T38138	ACEA 2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide
	Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in ...
T62671	FAAH/MAGL-IN-3
	FAAH/MAGL-IN-3 (Compound 10) 是一种不可逆的脂肪酸酰胺水解酶 (FAAH)和单酰基甘油脂酶 (MAGL)双重抑制剂，能够作用于 FAAH (IC50: 179 nM) 和 MAGL (IC50: 759 nM)。FAAH/MAGL-IN-3 表现出很小的 PAMPA (平行人工膜渗透性试验) 透过性。
T73317	JZP-MA-13
	JZP-MA-13是一种选择性α/β-水解酶结构域6 (ABHD6) 抑制剂，其IC50值为392 nM。该化合物对MAGL、ABHD12、FAAH或其它丝氨酸水解酶不表现出抑制作用。JZP-MA-13还被用作ABHD6在体内成像的正电子发射断层扫描(PET)配体。
T35786	O-7460
	In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM). It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 μM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 μM). At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-depe...

化合物

Cat.No: T6043

Target: FAAH, Autophagy

4-Nonylphenylboronic acid

Cat.No: T7688

Target: FAAH

Cat.No: T2684

Synonym: JNJ1661010,Takeda-25,JNJ 1661010

Target: FAAH

Cat.No: T9967

Target: Lipid

Cat.No: T28353

Target: FAAH

Cat.No: T8646

Target: FAAH

Cat.No: T3215

Synonym: JNJ42165279

Target: FAAH, Autophagy

Cat.No: T2338

Target: FAAH, Lipase, Autophagy

Cat.No: T8927

Synonym: WWL-154

Target: FAAH

Cat.No: T4323

Synonym: PF04457845,PF 04457845

Target: FAAH, Autophagy

Cat.No: T3354

Synonym: BIA10-2474

Target: FAAH, Autophagy

Cat.No: T15802

Target: FAAH, Autophagy

Cat.No: T1325

Synonym: 卡洛芬,Ridamyl,Imadyl,Rimadyl

Target: FAAH, COX, Autophagy

Cat.No: T9374

Synonym: 1-Piperidinecarboxylic acid, 4-nitrophenyl ester

Target: FAAH, Lipase, MAGL

FAAH inhibitor 1

Cat.No: T11256

Synonym: Benzothiazole analog 3

Target: FAAH

Cat.No: T15268

Synonym: O-Desmorpholinopropyl Gefitinib,4-(3-氯-4-氟苯氨基)-7-甲氧基喹唑啉-6-醇

Target: FAAH, Autophagy

Cat.No: T6714

Synonym: KDS-4103,FAAH Inhibitor II

Target: Mitophagy, FAAH, Autophagy

Cat.No: T28059

Synonym: MK4409,MK 4409

Cat.No: T27405

Synonym: GAT-211,AZ-4,GAT 211,AZ 4,AZ4

Cat.No: T28076

Target: FAAH

Dual FAAH/sEH-IN-1

Cat.No: T63536

Target: FAAH, Epoxide Hydrolase

Cat.No: T15635

Target: Lipase, MAGL

Cat.No: T68492

Synonym: HDSF,Hexadecanesulfonyl fluoride

Target: FAAH

CB2R/FAAH modulator-1

Cat.No: T67896

Target: Cannabinoid Receptor, FAAH

Cat.No: T26311

Synonym: URB-532,FAAH Inhibitor I,FAAH Inhibitor-I,URB 532

Cat.No: T29045

Cat.No: T68407

Cat.No: T12827

Target: Others

Cat.No: T16847

Target: FAAH

Cat.No: T27681

Synonym: JNJ40355003

Cat.No: T11255

Target: FAAH

Cat.No: T40775

Synonym: SSR411298

Cat.No: T71307

Decanoyl chloride

Cat.No: T71995

Cat.No: T28007

Cat.No: T78593

Target: FAAH

Cat.No: T61380

Palmitoyl-L-aspartic acid

Cat.No: T25918

Synonym: L-N-Palmitoylaspartic acid

N-Decanoyl p-Nitroaniline

Cat.No: T37217

Cat.No: T61198

Cat.No: T33789

Synonym: N-Oleoyl-l-proline

Cat.No: T62558

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide

Cat.No: T38223

Cat.No: T38143

Cat.No: T73302

Isopropyl dodec-11-enylfluorophosphonate

Cat.No: T78674

Synonym: IDEFP

Target: FAAH

Cat.No: T38138

Synonym: 2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide

Cat.No: T62671

Cat.No: T73317

Cat.No: T35786

Cat. No.	Product Name	Target	Signaling Pathways
T2859	Biochanin A 4-Methylgenistein,鹰嘴豆芽素A,Olmelin	EGFR; FAAH; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Biochanin A (4-Methylgenistein) 是一种从红三叶车轴草中分离出来的异黄酮衍生物，具有抗癌特性。它是脂肪酸酰胺水解酶抑制剂，作用于小鼠、大鼠和人 FAAH，IC50分别为 1.8、1.4 和 2.4 μM。
TN1965	N-Benzyllinolenamide N-苄基-(9Z,12Z,15Z)-十八碳三烯酰胺,N-Benzyllinolenamide	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	N-Benzyllinolenamide 是从玛卡中得到的一种生物碱，是脂肪酰胺水解酶抑制剂，IC50 为 41.8 μM。
T12139	N-(3-Methoxybenzyl)Palmitamide N-(3-甲氧基苄基)十六碳酰胺,玛卡酰胺杂质5	FAAH	Metabolism; Neuroscience
	N-(3-Methoxybenzyl)Palmitamide 是FAAH 抑制剂，可用于研究疼痛，炎症和中枢神经系统退行性疾病。
T3S2105	N-Benzylpalmitamide Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide	Others; FAAH; Autophagy	Autophagy; Metabolism; Neuroscience; Others
	N-Benzylpalmitamide (Macamide 1) 是从玛卡中得到的一种生物碱，可以时间依赖性方式抑制脂肪酸酰胺水解酶，有治疗疼痛、炎症和中枢神经系统退行性疾病的研究潜力。
T4859	1-Monomyristin rac-Glycerol 1-myristate,Glyceryl myristate,1-肉豆蔻酸单甘油酯,肉豆寇酸单甘油酯,Monomyristin,2,3-Dihydroxypropyl tetradecanoate	Others; FAAH; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal	Autophagy; Metabolism; Microbiology/Virology; Neuroscience; Others
	1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) 是从 Serenoa repens 中提取的，抑制脂肪酸酰胺水解酶活性(IC50=18 μM) 和 2-油酰甘油的水解 (IC50=32 μM)。它对白色念珠菌有抗真菌活性，对金黄色葡萄球菌和聚集性放线菌有抗菌活性。
T16075	(Rac)-Idroxioleic acid 2-Hydroxyoleic acid,2-OHOA,2-羟基乳清酸,Minerval	Apoptosis	Apoptosis
	(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) 是一种具有抗肿瘤作用的脂肪酸酰胺水解酶抑制剂。它与质膜结合并改变脂质组织。

天然产物

Cat.No: T2859

Synonym: 4-Methylgenistein,鹰嘴豆芽素A,Olmelin

Target: EGFR, FAAH, Autophagy

N-Benzyllinolenamide

Cat.No: TN1965

Synonym: N-苄基-(9Z,12Z,15Z)-十八碳三烯酰胺,N-Benzyllinolenamide

Target: FAAH, Autophagy

N-(3-Methoxybenzyl)Palmitamide

Cat.No: T12139

Synonym: N-(3-甲氧基苄基)十六碳酰胺,玛卡酰胺杂质5

Target: FAAH

N-Benzylpalmitamide

Cat.No: T3S2105

Synonym: Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide

Target: Others, FAAH, Autophagy

Cat.No: T4859

Synonym: rac-Glycerol 1-myristate,Glyceryl myristate,1-肉豆蔻酸单甘油酯,肉豆寇酸单甘油酯,Monomyristin,2,3-Dihydroxypropyl tetradecanoate

Target: Others, FAAH, Endogenous Metabolite, Antibacterial, Autophagy, Antifungal

(Rac)-Idroxioleic acid

Cat.No: T16075

Synonym: 2-Hydroxyoleic acid,2-OHOA,2-羟基乳清酸,Minerval

Target: Apoptosis

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